Design and Synthesis of Electrochemical Sensor Based on Cobalt Alumina Nanoparticles for Measuring Acyclovir in Biological Samples

Recently, many researches have been focused on the measurement of drugs in real samples, including blood serum, due to its high importance. Electrochemical methods have attracted more attention due to their many advantages, including: simplicity, response speed, lower cost, no need for complex sample preparation, etc. In this research, an electrochemical sensor with good performance and low cost was designed to measure acyclovir using nanomaterials. For this purpose, cobalt aluminate nanoparticles were synthesized by very simple methods, then analysis and characterization of the synthesized nanomaterials were performed using scanning electron microscopy, infrared spectroscopy and X-ray spectrometer. Then new electrochemical sensors based on synthesized nanomaterials were prepared. The performance of the designed sensor was measured in electrochemical probe solution. An electrochemical sensor for measuring acyclovir was prepared using cobalt aluminate, which has excellent conductivity. An electrochemical sensor based on cobalt alumina modified carbon paste electrode provided a diagnostic limit of 0.02 Some for acyclovir. The prepared sensor was used to measure the desired drug in the real sample using the standard augmentation method and showed a very good capability. The prepared sensor is also able to measure the desired drug in the presence of various compounds.